Week 4 of the NFL Football season has come and gone. It was a wild week, one that saw 7 surprising upsets, where the underdog teams won their games, outright. We reset and move on to NFL Week 5.
This Sunday features another International game with Philadelphia versus Jacksonville, in London, (930am EST on Sunday). Let’s get right into our Week 5 NFL Picks.
SafePicks NFL Picks: NFL WEEK 5 (2026 – 2027 NFL SEASON, Thur. Oct. 8 – Mon. Oct. 12, 2026):
| VISITOR | HOME | SU | ATS |
| TB | DAL -7.5 (T) | DAL | TB |
| PHI | JAC -7.5 (I, L) | JAC | JAC |
| CIN -7.5 | MIA | CIN | CIN |
| CLE | NYJ -2.5 | CLE | CLE |
| HOU -7.5 | TEN | HOU | TEN |
| IND | PIT -2.5 | IND | IND |
| LV | NE -3.5 | NE | LV |
| MIN -1.5 | NO | MIN | MIN |
| NYG | WSH -3.5 | WSH | NYG |
| CHI -2.5 | GB | CHI | CHi |
| DEN -3.5 | LAC | DEN | DEN |
| DET -5.5 | ARZ | DET | ARZ |
| SF | SEA -2.5 | SEA | SEA |
| BAL | ATL -3.5 | ATL | ATL |
| BUF | LAR -3.5 (M) | BUF | BUF |
| BYES: CAR, KC |
Please note: all games are played on Sunday, except as noted and our NFL picks are in SU and ATS format: (W = Wednesday, T = Thursday, F = Friday, M = Monday, I, L = International Game in London, SU = Straight Up, ATS = Against The Spread).
For the record…
LAST WEEK SU: 8 – 8
YEAR TO DATE SU: 39 – 25
LAST WEEK ATS: 10 – 6
YEAR TO DATE ATS: 35 – 29
Remember to check back here each week for our SafePicks NFL Picks.
All weekly NFL picks & NFL predictions will be posted here on Wednesdays by 11pm EST but almost always…. sooner.
Good luck to all this week!