NFL Week 5 has come and gone. We are on to Week 6 of the 2026 NFL Football season.
This week will feature a 14-game schedule as four teams will be on their bye week off. Also, this Sunday, will feature yet another International game with Houston and Jacksonville meeting in London, (930am EST on Sunday). It will be the 2nd consecutive week of NFL Football in London, for Jacksonville.
Let’s get right into our Week 6 NFL Picks.
SafePicks NFL Picks: NFL WEEK 6 (2026 – 2027 NFL SEASON, Thur. Oct. 15 – Mon. Oct. 19, 2026):
| VISITOR | HOME | SU | ATS |
| SEA -2.5 | DEN (T) | SEA | DEN |
| HOU | JAC -3 (I, L) | JAC | JAC |
| BAL -4.5 | CLE | CLE | CLE |
| CAR | PHI -1.5 | PHI | PHI |
| CHI -2.5 | ATL | CHI | ATL |
| NO -1.5 | NYG | NYG | NYG |
| NYJ | NE -6.5 | NE | NE |
| PIT -2.5 | TB | PIT | PIT |
| TEN | IND -6.5 | IND | IND |
| ARZ | LAR -12.5 | LAR | ARZ |
| BUF -4.5 | LV | BUF | LV |
| LAC | KC -8.5 | KC | LAC |
| DAL | GB -1.5 | GB | GB |
| WSH | SF -7.5 (M) | SF | SF |
| BYES: CIN, DET, MIA, MIN |
Please note: all games are played on Sunday, except as noted and our NFL picks are in SU and ATS format: (W = Wednesday, T = Thursday, F = Friday, M = Monday, I, L = International Game in London, SU = Straight Up, ATS = Against The Spread).
For the record…
LAST WEEK SU: 9 – 6
YEAR TO DATE SU: 48 – 31
LAST WEEK ATS: 7 – 8
YEAR TO DATE ATS: 42 – 37
Remember to check back here each week for our SafePicks NFL Picks.
All weekly NFL picks & NFL predictions will be posted here on Wednesdays by 11pm EST but almost always…. sooner.
Good luck to all this week!